I've mixed small amounts of both into one shot, it's a great rush followed by a nice long duration from the Opana.I do caution that if you try this to start out really low on the mgs and test your own tolerance against this style....like Chronicpain always says...you can always take more but you can't take it back out. I do know of people that have shot one and then made a shot of the other and experienced mild overdose symptons such as vomiting in a cycle like period every so many minutes.